Protein name:
Signaling lymphocytic activation molecule ;
Alternative:
IPO-3 ;CDw150 ;
CD:
CD150 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts (via cytoplasmic domain) with SH2D1A, and with PTPN11. Interacts with INPP5D/SHIP1. Binds to Measles virus H protein and acts as a receptor for this virus.
Function:
High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.
Subcellular Location:
Cell membrane
Single-pass type I membrane protein
Present on the surface of B-cells and T-cells.
Protein Attributes:
50:
MDPKGLLSLT | FVLFLSLAFG | ASYGTGGRMM | NCPKILRQLG | SKVLLPLTYE |
100:
RINKSMNKSI | HIVVTMAKSL | ENSVENKIVS | LDPSEAGPPR | YLGDRYKFYL |
150:
ENLTLGIRES | RKEDEGWYLM | TLEKNVSVQR | FCLQLRLYEQ | VSTPEIKVLN |
200:
KTQENGTCTL | ILGCTVEKGD | HVAYSWSEKA | GTHPLNPANS | SHLLSLTLGP |
250:
QHADNIYICT | VSNPISNNSQ | TFSPWPGCRT | DPSETKPWAV | YAGLLGGVIM |
300:
ILIMVVILQL | RRRGKTNHYQ | TTVEKKSLTI | YAQVQKPGPL | QKKLDSFPAQ |
335:
DPCTTIYVAA | TEPVPESVQE | TNSITVYASV | TLPES
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Dog
Human
Mouse
ELISA Kit for Human Signaling lymphocytic activation molecule
ELISA Kit for Human Signaling lymphocytic activation molecule
ELISA Kit for Human Signaling lymphocytic activation molecule
CLIA Kit for Human Signaling lymphocytic activation molecule
CLIA Kit for Human Signaling lymphocytic activation molecule
CLIA Kit for Human Signaling lymphocytic activation molecule
Polyclonal Antibody for Human Signaling lymphocytic activation molecule
Polyclonal Antibody for Human Signaling lymphocytic activation molecule
Polyclonal Antibody for Human Signaling lymphocytic activation molecule
Monoclonal Antibody for Human Signaling lymphocytic activation molecule
Monoclonal Antibody for Human Signaling lymphocytic activation molecule
Monoclonal Antibody for Human Signaling lymphocytic activation molecule
Protein for Human Signaling lymphocytic activation molecule
Protein for Human Signaling lymphocytic activation molecule
Protein for Human Signaling lymphocytic activation molecule
R&D Technical Data
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Precision
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Recovery
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Linearity
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